MediciNova compounds demonstrate novel therapeutic approach for Atherosclerosis

MediciNova (MNOV) and the Standard Market of the Tokyo Stock Exchange announces the publication of a new research article in the peer-reviewed Journal of Atherosclerosis and Thrombosis, the official journal of the Japan Atherosclerosis Society and the Asian Pacific Society of Atherosclerosis and Vascular Disease. The study, titled, “Enhancement of ABCA1 and ABCG1 Expression and Cholesterol Efflux by a Metabolite of Tipelukast: A Potential Therapeutic Strategy for Atherosclerosis,” is the result of a collaboration effort between MediciNova and a leading Japanese academic research group specializing in lipid and cholesterol metabolism. The research demonstrated that MN-002, the major metabolite of Company’s investigational compound MN-001 (tipelukast), significantly enhanced cholesterol efflux in macrophages by upregulating key transport proteins ABCA1 and ABCG. These findings suggest a novel mechanism of action and potential therapeutic strategy for atherosclerosis and other metabolic disorders.