Klotho Neurosciences, ORCLS announce plan to study Blue Zone

Klotho Neuroscience has announced that it is partnering with Makoto Suzuki, Craig and Bradley Willcox, Richard Allsopp, and Michio Shimabukuro of the Okinawa Research Center for Longevity Science, or ORCLS, as part of its research program on Okinawa, Japan, where a comparatively high number people live extremely long and healthy lives, many reaching 100 years and more. Okinawa is the original Blue Zone, validated by nearly five decades of research by ORCLS, which led to the discovery of other “longevity hotspots” – areas of the world with high concentrations of where people live to exceptional ages, extending not only their lifespans but their healthspans. KLTO has preliminary data from ORCLS suggesting the human alpha-Klotho gene and its secreted alpha-Klotho protein isoform may contribute to healthy longevity and lifespan. As we grow old, a-Klotho blood and tissue levels decrease. The decrease in tissue levels precedes the onset of multiple pathologies and diseases of human organ systems. Importantly, replenishing the s-KL levels using gene therapy may help protect against neurodegenerative disorders, muscle loss, bone loss and heart, liver and kidney disfunction associated with aging.