Kalaris Therapeutics now enrolling Phase 1b/2 MAD study of TH103

Kalaris Therapeutics (KLRS) announced that it is now enrolling a Phase 1b/2 multiple ascending dose, MAD, study of TH103 in patients with neovascular age-related macular degeneration, nAMD. The study is intended to build upon the company’s ongoing Phase 1a single ascending dose, SAD, study and represents a key advance in the clinical development program for TH103 towards potential Phase 3 clinical development. The new Phase 1b/2 dose-finding study is designed to evaluate multiple dose levels of TH103 in up to 80 nAMD patients. Patients will receive up to 4 initial monthly intravitreal injections of TH103. Study assessments are expected to include safety and preliminary efficacy with a primary time point for analysis at one-month following the last injection. Patients will then be followed in an extension phase of the study.