HCW Biologics announces results from second-gen T-cell engager programs

HCW Biologics (HCWB) announced that its scientists have successfully developed second-generation, tissue factor-targeting T-cell engagers against solid tumors, particularly for pancreatic cancer and glioblastoma, constructed with its novel proprietary TRBC product discovery and development platform technology. The company said, “First generation TCEs continue to face a number of significant challenges such as antigen selection, efficacy for solid tumors, tolerability, safety, and complex manufacturing processes. HCW Biologics believes its second-generation TCEs could alleviate such shortfalls. The Company has constructed TCEs that have shown in preclinical studies to not only target cancer antigens and CD3 activation of effector T cells, but also simultaneously reduce immunosuppression in the tumor microenvironment. Reports have shown that such immunosuppression plays a pivotal role in reducing effector T-cell infiltration and anti-tumor efficacy in solid tumors. The Company’s two lead TCEs target tumor-expressed tissue factor and mesothelin, and its lead product candidates exhibit potent and antigen-specific anti-pancreatic cancer activities both in vitro and in humanized mouse models through subcutaneous injections.”