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Fractyl Health initiated with a Buy at Canaccord

Canaccord initiated coverage of Fractyl Health (GUTS) with a Buy rating and $12 price target Local administration to the pancreas combined with GLP-1 expression controlled by an insulin promoter means GLP-1 expression increases after food intake, the analyst tells investors in a research note. The firm believes Fractyl’s “Smart GLP-1” gene therapy platform Rejuva might be the solution. The company’s lead candidate RJVA-001 will enter clinical testing in type 2 diabetes in the first half of 2025, with initial data expected in 2026, notes Canaccord.

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