Coya files U.S patents for COYA 301 + GLP-1 receptor agonists

Coya Therapeutics announces the filing of intellectual property protection for the combination of COYA 301, or recombinant human low dose interleukin-2 and Glucagon-Like Peptide-1 receptor agonists . Dr. Arun Swaminathan, Coya’s Chief Business Officer, stated, “There has been an upswing in interest from major pharma companies looking to expand their GLP-1 RA pipeline including testing combination mechanistic approaches. The combination of low-dose IL-2 with GLP-1 RAs could offer a differentiated approach to addressing multiple conditions, including in neurodegenerative conditions such as Alzheimer’s Disease, in which GLP-1 RAs have recently shown promise. We believe the potential of this proprietary combination could lead to value-creating business development partnerships.” There has been extensive commercial success using the GLP-1 RA class for the treatment of diabetes and obesity. GLP-1 RAs have anti-inflammatory and anti-oxidant effects that may contribute to their overall glucose-lowering benefits. The influence of GLP-1 RAs on inflammatory pathways provides an opportunity to optimize these effects by combining with LD IL-2 mediated Treg enhancement.