Calidi presents new data on in situ t-cell engagers at AACR

Calidi (CLDI) Biotherapeutics presented new data at the American Association of Cancer Research, AACR, annual meeting in San Diego, California on April 19, 2026. The Company demonstrated new data on its approach of simultaneously activating T-cells while inducing the expression of T-cell engagers specifically in situ in the tumor microenvironment, TME. RedTail is Calidi’s systemically delivered virotherapy platform designed to selectively target tumors, remodel the TME, and enable high-level expression of therapeutic genetic payloads directly at the tumor site while limiting peripheral exposure. CLD-401, the lead candidate derived from the RedTail platform, is engineered to express high levels of IL-15 superagonist, a known CD8 T-cell, NK cell, and gamma delta T-cell activator, in the TME. The Company expects to file an IND for CLD-401 by the end of 2026.