Bright Minds says BMB-201 outperforms sumatriptan in preclinical model

Bright Minds (DRUG) Biosciences announced preclinical results for its investigational compound BMB-201, in a validated isosorbide dinitrate rat model of vascular headache. BMB-201 produced statistically significant reductions in facial mechanical allodynia across both male and female cohorts at 1 and 2 hours post-dose, compared to vehicle, and demonstrated greater effect sizes than sumatriptan at multiple timepoints. Key Results: Robust efficacy versus vehicle at 1 and 2 hours in both sexes. Benchmark comparison: BMB-201 showed greater effect sizes than sumatriptan at multiple timepoints and doses. These effect sizes reflect statistically significant improvements versus vehicle. Consistent activity across sexes and aligned with a nitric-oxide trigger paradigm. “BMB-201 delivered strong and reproducible activity in a stringent vascular headache model, with efficacy signals that exceeded sumatriptan at multiple timepoints. This further validates the use of 5-HT2 agonists in pain management,” said Jan Torleif Pedersen, Chief Science Officer of Bright Minds Biosciences.