Athira Pharma to present data from first-in-human Phase 1 trial of ATH-1105

Athira Pharma (ATHA) announced that the Company will present data from a Phase 1 clinical trial of ATH-1105 in healthy volunteers at the 4th Annual ALS drug Development Summit taking place from May 12-14, 2025 in Boston, Massachusetts. ATH-1105 is the Company’s novel, orally available, brain-penetrant, next-generation small molecule drug candidate designed to positively modulate the neurotrophic HGF system for the potential treatment of neurodegenerative diseases, including amyotrophic lateral sclerosis. The data will be highlighted in an oral presentation titled, “Advancing ATH-1105 for ALS Through Early Clinical and PK Data,” on Tuesday, May 13, 2025, at 11 am ET and a poster presentation titled, “ATH-1105 Enhances Motor Neuron Survival and Reduces TDP-43 Pathology in Preclinical ALS Models,” on Tuesday, May 13, 2025, at 3 p.m. ET. The data, to be presented by Sherif Reda, Ph.D., Director, Discovery Research at Athira Pharma, and Kai-Bin Ooi, Director, Drug Development and Operations at Athira Pharma, will feature preclinical and Phase 1 data supporting the continued clinical development of ATH-1105 in ALS. Key Highlights from the Presentation: ATH-1105 has demonstrated consistent and robust beneficial effects in preclinical models of ALS; ATH-1105 showed a favorable safety profile and was well tolerated in both single and multiple ascending dose studies in healthy volunteers; ATH-1105 showed dose proportional pharmacokinetics and central nervous system penetration.