Atea Pharma publishes data on metabolic activation pathway of bemnifosbuvir

Atea Pharmaceuticals announced that data highlighting the metabolic activation pathway of bemnifosbuvir were published in the peer-reviewed journal, PLOS Biology, in an article titled, “The activation cascade of the broad-spectrum antiviral bemnifosbuvir characterized at atomic resolution.” Bemnifosbuvir, an oral nucleotide RNA-dependent RNA polymerase RdRp inhibitor, is in Phase 3 development for the treatment of COVID-19 and in Phase 2 development in combination with ruzasvir, an oral NS5A inhibitor, for the treatment of hepatitis c virus HCV infection…”With these new data, we now have a better understanding of how bemnifosbuvir confers its antiviral activity, as this study identifies the individual enzymes involved in the activation pathway of bemnifosbuvir and clarifies their structural and functional mode of interaction with activation intermediates. This scientific work contributes further to the scientific understanding of bemnifosbuvir and its selective mechanism of action as a direct-acting antiviral,” said Bruno Canard, PhD, lead investigator of the study at Architecture et Fonction des Macromolecules Biologiques, CNRS and Aix-Marseille University.