Aptevo Therapeutics provides program update for APVO711

Aptevo Therapeutics (APVO) provided a program update for APVO711, a dual mechanism bispecific utilizing the PD-L1 arm to block the PD-1/PD-L1 pathway and the CD40 arm to enhance T cell priming through activation of the stimulatory receptor CD40 on antigen presenting cells. This update highlights the depth and scientific versatility of Aptevo’s existing pipeline and reinforces the Company’s ability to advance differentiated candidates for solid tumors with significant unmet need. Currently in preclinical development, APVO711 reflects the potential of Aptevo’s platform-based strategy to generate bispecific therapeutics with novel mechanisms and broad clinical relevance. “With APVO711, we’re advancing an innovative dual-mechanism approach to immunotherapy-one that not only boosts the immune system through PD-L1 blockade but also facilitates T-cell priming via CD40 activation. This is important in the development of new therapeutics for cancers that have proven resistant to standard checkpoint therapies. We believe APVO711 has the potential to unlock deeper, more sustained responses, and ultimately expand the reach of immunotherapy to patients who need it most,” said Marvin White, President and CEO of Aptevo.