AN2 Therapeutics gets continuation grant to discover novel boron based therapies

AN2 Therapeutics announced that the company has received a second year continuation of a research grant from the Bill & Melinda Gates Foundation to discover novel, boron containing small molecules for the treatment of tuberculosis TB and malaria. ” “Our boron chemistry platform and team have a proven history of developing innovative compounds with novel mechanisms of action that address critical unmet needs in infectious diseases and other therapeutic areas. This grant highlights the potential of our boron chemistry platform and supports our commitment to address these critical gaps in global health therapeutics through non-dilutive funding.” This grant continuation from the foundation will support the discovery of novel inhibitors of aminoacyl-tRNA synthetases using AN2’s proprietary boron chemistry platform to identify new therapies for TB and malaria. Leucyl- tRNA synthetase is a validated human target in Mycobacteria and other bacteria and fungi and has the potential to address significant unmet needs in the antimicrobial space, including TB and nontuberculous Mycobacteria lung disease. This program builds on the scientific accomplishments and expertise of several AN2 scientists who were involved in discovering novel leucyl-tRNA synthetase inhibitors that leverage the power of boron chemistry including epetraborole tavaborole and ganfeborole, which is currently in development for tuberculosis by GSK.