Alterity Therapeutics presents new data analyses from ATH434 trial

Alterity Therapeutics (ATHE) announced the presentation of new data analyses from the Phase 2 trial of ATH434, demonstrating clinical efficacy in patients with Multiple System Atrophy. The analysis was delivered in an oral presentation during a Late Breaking Science Session at the American Academy of Neurology annual meeting taking place in Chicago. The presentation, entitled, “ATH434 Demonstrates Disease-Modifying Signal in Multiple System Atrophy Using the MuSyCA Composite Scale,” described an analysis from the ATH434-201 Phase 2 clinical trial in MSA utilizing the MSA Combined Outcome Assessment. The MuSyCA is a newly developed scale that includes 11 items from both the UMSARS1 I and UMSARS II with highest standardized effect sizes across four MSA cohorts and is intended to improve detection of disease progression in clinical trials. Assessment of the ATH434-201 trial showed results utilizing MuSyCA. MuSyCA demonstrated sensitivity to disease progression with placebo participants worsening by approximately +9.7 points over 52 weeks, confirming the scale is sensitive to change over the study period. Consistent with prior data, ATH434 slowed disease progression on the MuSyCA assessment with a treatment effect of -1.9 to -4.0 points at Week 52. In contrast, when utilizing a MMRM3 statistical analysis, ATH434 slowed disease progression on the modified UMSARS I versus placebo by -3.1 points at 75 mg and -4.7 points at 50 mg.