In a report released today, Andrew Fein from H.C. Wainwright reiterated a Buy rating on Wave Life Sciences, with a price target of $30.00.
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Andrew Fein has given his Buy rating due to a combination of factors tied to the differentiated profile of WVE-007 and its market potential. His team’s analysis and dose-response modeling suggest that WVE-007 can meaningfully reduce visceral fat while simultaneously increasing lean muscle mass, without provoking the gastrointestinal side effects commonly observed with existing obesity treatments. Key opinion leaders he consulted view this “body recomposition” profile as addressing a meaningful clinical gap, especially for patients who need to preserve or restore muscle while reducing the high‑risk visceral fat that drives cardiovascular complications. Fein also notes that higher dosing appears capable of achieving fat-loss rates that are competitive with current standards of care, while the favorable safety profile supports the prospect of a strong, differentiated commercial label.
In addition, Fein emphasizes that physicians see WVE-007 as well-positioned to serve both as a maintenance therapy after GLP-1–induced weight loss and as a complementary agent that could be combined with GLP-1s to mitigate muscle loss and weight regain. This dual role enlarges the drug’s potential market and reinforces its strategic value within the broader obesity-treatment landscape. He further interprets upcoming competitor data not as a direct competitive threat but as further validation of the INHBE-targeting approach, which could lift the entire class and spotlight Wave’s “quality-over-quantity” positioning. Together, these clinical, mechanistic, and market dynamics support Fein’s conviction in Wave Life Sciences’ upside and underpin his Buy rating and increased price target.
In another report released yesterday, Wedbush also maintained a Buy rating on the stock with a $33.00 price target.