Matthew Caufield, an analyst from H.C. Wainwright, maintained the Hold rating on Unity Biotechnology (UBX – Research Report). The associated price target was lowered to $2.00.
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Matthew Caufield has given his Hold rating due to a combination of factors surrounding Unity Biotechnology’s recent developments. The company is undergoing significant management transitions, with key roles such as CEO, CFO, and Chief Legal Officer moving into consulting positions as Unity evaluates strategic alternatives. This uncertainty in leadership is compounded by the recent miss of the primary endpoint in the Phase 2B ASPIRE study for UBX1325, which did not achieve non-inferiority compared to aflibercept in diabetic macular edema patients at the average of weeks 20 and 24.
Despite these setbacks, UBX1325 has shown promise in other areas, demonstrating non-inferiority to aflibercept in 9 out of 10 time points through 36 weeks, and achieving vision gains in certain patient subgroups. The company is exploring strategic alternatives to advance the UBX1325 program, including potential partnerships and new pipeline mechanisms. While these findings offer potential for future development, the current lack of clarity on strategic direction and management changes have led to a more cautious outlook, resulting in the Hold rating.
Caufield covers the Healthcare sector, focusing on stocks such as Aldeyra Therapeutics, Unity Biotechnology, and Immunic. According to TipRanks, Caufield has an average return of -13.7% and a 33.33% success rate on recommended stocks.
In another report released on May 19, Mizuho Securities also downgraded the stock to a Hold with a $1.00 price target.