Analyst Emily Bodnar of H.C. Wainwright maintained a Buy rating on MiNK Therapeutics, retaining the price target of $35.00.
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Emily Bodnar’s rating is based on the promising results from MiNK Therapeutics’ Phase 1 trial of agenT-797 in combination with anti-PD-1 therapy for relapsed/refractory solid tumors. The trial demonstrated significant overall survival benefits, particularly in combination therapy, with a median overall survival of approximately 23 months compared to 5.6 months for monotherapy. The safety profile of agenT-797 was favorable, with no severe neurotoxicity or cytokine release syndrome observed, making it a well-tolerated treatment option.
Additionally, the mechanism of action of agenT-797, which involves dual TCR-dependent and TCR-independent pathways, shows potential for immune reactivation and tumor microenvironment remodeling. This includes enhancing CD8+ and NK cell infiltration and activating pro-inflammatory cytokines, which could lead to a potent yet controlled immune response. Given these positive outcomes, MiNK plans to advance to additional Phase 2 trials, which supports the Buy rating as the therapy holds promise as a first-in-class treatment for difficult-to-treat solid tumors.