In a report released yesterday, Tazeen Ahmad from Bank of America Securities reiterated a Sell rating on Fulcrum Therapeutics, with a price target of $7.00.
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Tazeen Ahmad’s rating is based on a combination of factors that highlight potential challenges for Fulcrum Therapeutics. Despite some positive interim data from the PIONEER study, which showed a dose response in severe sickle cell disease (SCD) patients, the results were not as robust as expected. The increase in hemoglobin levels was lower than anticipated, which is crucial for demonstrating disease modification.
Additionally, the market opportunity for pociredir, Fulcrum’s drug candidate, is highly dependent on FDA discretion and the expansion of its addressable patient population. The company’s plans to initiate a registrational study and the potential delay in launching the drug until 2029 also contribute to the cautious outlook. These factors, combined with the current stock price being above the price objective, support the Underperform rating.