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Cautious Optimism for Shattuck Labs: Hold Rating Amid Promising SL-325 Developments and Financial Stability

H.C. Wainwright analyst Joseph Pantginis has maintained their neutral stance on STTK stock, giving a Hold rating today.

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Joseph Pantginis has given his Hold rating due to a combination of factors including Shattuck Labs’ financial position and the progress of its lead program, SL-325. The company recently reported its first-quarter 2025 results, showing an EPS that was better than expected, and it maintains a solid cash position expected to support operations into 2027. This financial stability provides a foundation for advancing SL-325, a promising DR3 antagonist antibody aimed at treating inflammatory bowel disease.
Despite the positive preclinical data and the potential differentiation of SL-325 from other treatments targeting the TL1A/DR3 signaling pathway, the program is still in early stages with an IND filing expected in the third quarter of 2025 and a Phase 1 trial projected to start soon after. Given these timelines, the Hold rating reflects a cautious optimism, acknowledging the potential of SL-325 while considering the inherent risks and uncertainties associated with early-stage drug development.

According to TipRanks, Pantginis is an analyst with an average return of -19.8% and a 22.78% success rate. Pantginis covers the Healthcare sector, focusing on stocks such as Viking Therapeutics, Cytokinetics, and Actinium Pharmaceuticals.

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