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Triple Agonist Obesity Drug Data Underscore Competitive Pressure in GLP-1 Field

Triple Agonist Obesity Drug Data Underscore Competitive Pressure in GLP-1 Field

According to a recent LinkedIn post from BioSpectator Inc, new phase 2 data for a triple agonist obesity drug candidate from The United Bio-Technology, UBT251, are beginning to emerge. The post notes that, at 24 weeks, the GLP-1/GIP/GCG triple agonist reportedly achieved up to 19.7% weight loss, although detailed data have not yet been disclosed.

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The company’s LinkedIn post highlights that these preliminary results appear competitive versus Eli Lilly’s leading triple agonist candidate retatrutide, which showed up to 17.5% weight loss at the highest 12 mg dose in a phase 2 trial. However, the post also underscores Lilly’s significant lead, with an initial phase 3 readout already reported in December and seven phase 3 studies expected to complete within this year, suggesting a challenging environment for later entrants and partners such as Novo Nordisk that are seeking next-generation obesity assets.

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