Breakthrough Properties Lands Major Biopharma Expansion at Harvard ERC Flagship One Milestone

New updates have been reported about Breakthrough Properties.

Breakthrough Properties has secured a major expansion commitment from a leading global biopharma company at One Milestone, its flagship life sciences development within Harvard’s Enterprise Research Campus (ERC) in Boston’s Allston district. The tenant, which previously agreed to lease 30,000 square feet for a new Innovation Center, will now take 100,000 square feet—more than tripling its planned footprint—and begin phased occupancy in mid-2026. The expanded center will focus on Cardiovascular, Renal, and Metabolism (CVRM) discovery, as well as artificial intelligence and data science initiatives, significantly strengthening One Milestone’s role as a hub for advanced R&D and positioning Breakthrough’s campus as a key node in Boston’s biopharma ecosystem. Breakthrough CEO Dan Belldegrun described the Innovation Center as an ideal anchor tenant that validates the project’s mission to bridge academia and industry.

One Milestone, currently in advanced construction, is a two-building life sciences complex designed by Henning Larsen and Studio Gang to promote collaboration through shared amenities, including a high-spec conference facility and fitness center. The property is part of the ERC’s first phase, which broke ground in 2023 and is being jointly developed by Breakthrough Properties and Tishman Speyer alongside Harvard Allston Land Company. The broader mixed-use campus now includes Verra, a 343-unit residential community already 60% leased; the David Rubenstein Treehouse conference center, which opened in late 2025; the Atlas Hotel, opening winter 2026; 40,000 square feet of retail; and two acres of programmable public green space. For Breakthrough, the enlarged biopharma commitment de-risks a key portion of its Allston life science inventory, enhances asset visibility to additional tenants including high-growth companies seeking StudioLabs space, and reinforces its strategy of clustering lab, office, residential, hospitality, and academic linkages adjacent to Harvard’s Business School, Science and Engineering Complex, and Kempner Institute.