Vivoryon Therapeutics AG ((NL:VVY)) has held its Q2 earnings call. Read on for the main highlights of the call.
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Vivoryon Therapeutics AG’s recent earnings call painted a picture of both progress and challenges. The company has made significant strides in clinical and financial fronts, notably in reducing expenses and advancing its varoglutamstat program. However, concerns were raised about a reduced cash position and the necessity for additional financing to support future studies.
Significant Reduction in R&D Expenses
Vivoryon reported a substantial decrease in research and development expenses, dropping from EUR 10.3 million in the first half of 2024 to EUR 2.8 million in the same period of 2025. This reduction is attributed to decreased clinical development and production costs, reflecting the company’s efforts to optimize financial management.
Net Loss Reduction
The company achieved a notable reduction in net loss, reporting EUR 5.5 million for the first half of 2025, compared to EUR 13.6 million in the previous year. This improvement highlights Vivoryon’s effective financial strategies and management.
Strong Clinical Data for Varoglutamstat
Varoglutamstat has shown promising results in Phase II studies, demonstrating statistically significant and clinically meaningful improvements in kidney functions, particularly benefiting patients with diabetic kidney disease.
New U.S. Patent for Varoglutamstat
Vivoryon secured a new U.S. composition of matter patent for varoglutamstat, ensuring market exclusivity through 2044, with potential for extension. This patent strengthens the company’s market position and future revenue streams.
Preclinical Success in Diabetic Kidney Disease Model
In preclinical models, varoglutamstat exhibited impressive reductions in inflammation and fibrosis, further supporting its potential therapeutic benefits in diabetic kidney disease.
Positive Feedback from Scientific Community
The nephrology community has positively received Vivoryon’s data presented at major conferences, increasing interest and validation for varoglutamstat’s potential in treating kidney diseases.
Decreased Cash Position
Vivoryon’s cash and cash equivalents decreased to EUR 4.8 million as of June 30, 2025, from EUR 9.4 million at the end of 2024. This decline raises concerns about the company’s ability to fund future operations without additional financing.
Pending Financing for Phase IIb Study
The initiation of a dedicated Phase IIb study for varoglutamstat in diabetic kidney disease patients is dependent on securing additional financing, highlighting the company’s need for strategic financial planning.
Temporary Change in CFO Position
Anne Doering, the CFO, announced a temporary partial leave of absence due to a family health matter, with Marcus Irsfeld stepping in as acting CFO, ensuring continuity in financial leadership.
Forward-Looking Guidance
Vivoryon’s forward-looking guidance emphasizes continued focus on reducing expenses and advancing its varoglutamstat program. The company aims to extend its cash runway into January 2026, excluding funds from a standby equity purchase agreement. Strategic preparations for a Phase IIb study in diabetic kidney disease are underway, underscoring Vivoryon’s commitment to expanding its impact in the kidney disease market.
In summary, Vivoryon Therapeutics AG’s earnings call reflects a balanced narrative of progress and challenges. While the company has achieved significant reductions in expenses and demonstrated promising clinical data, the need for additional financing remains a critical focus. The overall sentiment is one of cautious optimism, with strategic plans in place to address financial and operational hurdles.