Shattuck Labs Refocuses Strategy Amidst Restructuring and Cuts

Shattuck Labs ( (STTK) ) just unveiled an announcement.

Shattuck Labs, Inc. has decided to terminate its collaboration with Ono Pharmaceutical and discontinue the clinical program for SL-172154, redirecting focus to SL-325, a promising DR3 antagonist antibody targeting the TL1A/DR3 signaling pathway with potential use in treating inflammatory bowel disease. This strategic shift follows modest improvements in overall survival for patients treated with SL-172154. The company is undergoing a significant restructuring, which includes a 40% workforce reduction and anticipates incurring restructuring charges, primarily related to severance costs. Despite these changes, Shattuck projects sufficient funds to support operations into 2027.

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