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Recursion Pharmaceuticals Reports Positive TUPELO Trial Results

Story Highlights
  • Recursion Pharmaceuticals announced positive results from the TUPELO trial of REC-4881 for FAP.
  • The trial showed durable reductions in polyp burden, validating Recursion’s AI-driven approach.
  • Looking for the best stocks to buy? Follow the recommendations of top-performing analysts.
Recursion Pharmaceuticals Reports Positive TUPELO Trial Results

TipRanks Cyber Monday Sale

Recursion Pharmaceuticals ( (RXRX) ) just unveiled an update.

On December 8, 2025, Recursion Pharmaceuticals announced positive results from the Phase 1b/2 TUPELO trial of REC-4881, an investigational MEK1/2 inhibitor for familial adenomatous polyposis (FAP). The trial demonstrated rapid and durable reductions in polyp burden, with 75% of patients showing improvement after 12 weeks of treatment, and 82% maintaining reductions 12 weeks post-treatment. These findings are significant given the lack of approved therapies for FAP, a condition with a high risk of colorectal cancer. The results validate Recursion’s AI-driven approach and suggest REC-4881 could offer a non-surgical treatment option, potentially impacting the company’s market positioning and providing hope for patients with FAP.

The most recent analyst rating on (RXRX) stock is a Hold with a $4.50 price target. To see the full list of analyst forecasts on Recursion Pharmaceuticals stock, see the RXRX Stock Forecast page.

Spark’s Take on RXRX Stock

According to Spark, TipRanks’ AI Analyst, RXRX is a Neutral.

Recursion Pharmaceuticals’ overall stock score is primarily impacted by its financial challenges, including declining revenues and persistent losses. While the company benefits from a strong cash position and strategic partnerships, the bearish technical indicators and negative valuation metrics weigh heavily on the score. Positive developments from corporate events and earnings call provide some support, but the financial instability remains a significant concern.

To see Spark’s full report on RXRX stock, click here.

More about Recursion Pharmaceuticals

Recursion Pharmaceuticals is a clinical-stage TechBio company focused on decoding biology to radically improve lives. The company leverages its AI-driven platform, Recursion OS, to discover and develop novel therapeutics, particularly targeting diseases with no approved pharmacotherapy options.

Average Trading Volume: 43,295,886

Technical Sentiment Signal: Sell

Current Market Cap: $2.45B

See more insights into RXRX stock on TipRanks’ Stock Analysis page.

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