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Rapport Therapeutics Reports Positive Phase 2a Trial Results

Story Highlights
  • Rapport Therapeutics reported positive results from a Phase 2a trial of RAP-219 for focal onset seizures.
  • The trial showed significant seizure reductions and good tolerability, supporting Phase 3 advancement.
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An update from Rapport Therapeutics, Inc. ( (RAPP) ) is now available.

On September 8, 2025, Rapport Therapeutics announced positive topline results from its Phase 2a clinical trial of RAP-219 in patients with drug-resistant focal onset seizures. The trial demonstrated statistically significant reductions in long episodes and clinical seizures, with 85.2% of patients achieving a ≥30% reduction in long episodes and 72.0% achieving a ≥50% reduction in clinical seizures. RAP-219 was generally well-tolerated, with no serious adverse events reported. These results support advancing RAP-219 into Phase 3 trials, highlighting its potential as a significant treatment option for patients with drug-resistant focal seizures.

The most recent analyst rating on (RAPP) stock is a Buy with a $42.00 price target. To see the full list of analyst forecasts on Rapport Therapeutics, Inc. stock, see the RAPP Stock Forecast page.

Spark’s Take on RAPP Stock

According to Spark, TipRanks’ AI Analyst, RAPP is a Neutral.

Rapport Therapeutics, Inc. faces significant challenges with no revenue and substantial operational losses despite strong equity financing and low leverage. Technical indicators point to a downward trend, and valuation is difficult to ascertain. Positive clinical trial results offer some optimism, but leadership changes contribute to uncertainty.

To see Spark’s full report on RAPP stock, click here.

More about Rapport Therapeutics, Inc.

Rapport Therapeutics, Inc. is a clinical-stage biotechnology company focused on developing small molecule precision medicines for neurological and psychiatric disorders.

Average Trading Volume: 179,032

Technical Sentiment Signal: Buy

Current Market Cap: $524.1M

For a thorough assessment of RAPP stock, go to TipRanks’ Stock Analysis page.

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