Pmv Pharmaceuticals, Inc. ((PMVP)) announced an update on their ongoing clinical study.
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PMV Pharmaceuticals, Inc. is conducting a clinical study titled ‘The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE).’ The study aims to assess the safety, tolerability, pharmacokinetics, pharmacodynamics, and efficacy of PC14586 in patients with locally advanced or metastatic solid tumors with a TP53 Y220C mutation. This study is significant as it targets a specific mutation in cancer treatment, potentially offering new therapeutic options for patients.
The intervention being tested is a drug named rezatapopt, a first-in-class, oral, small molecule p53 reactivator selective for the TP53 Y220C mutation. It is intended to reactivate the p53 protein, which plays a crucial role in controlling cell division and preventing tumor growth.
The study is designed as an interventional, non-randomized trial with a parallel assignment. It is open-label, meaning no masking is used, and its primary purpose is treatment. The study involves multiple phases, including dose escalation and expansion, to determine the optimal dosage and assess the drug’s effectiveness.
The study began on October 1, 2020, with the primary completion date yet to be determined. The most recent update was submitted on September 4, 2025. These dates are crucial for tracking the study’s progress and anticipated milestones.
The market implications of this study update are significant for PMV Pharmaceuticals, as positive results could enhance investor confidence and potentially boost the company’s stock performance. The involvement of Merck Sharp & Dohme LLC as a collaborator underscores the study’s importance in the competitive oncology landscape.
The study is ongoing, with further details available on the ClinicalTrials portal.