Pfizer Inc ((PFE)), Astellas Pharma ((ALPMF)), Astellas Pharma ((ALPMY)) announced an update on their ongoing clinical study.
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Pfizer Inc. and Astellas Pharma Inc. are conducting a Phase 3 clinical study titled ‘TALAPRO-3: A Phase 3, Randomized, Double-Blind, Study of Talazoparib With Enzalutamide Versus Placebo With Enzalutamide in Men With DDR Gene Mutated Metastatic Castration-Sensitive Prostate Cancer.’ The study aims to evaluate the safety and efficacy of combining talazoparib with enzalutamide compared to a placebo with enzalutamide in men with DDR-deficient metastatic castration-sensitive prostate cancer (mCSPC). This research is significant as it could lead to new treatment options for this patient group.
The study tests two interventions: an experimental combination of talazoparib and enzalutamide, and a placebo combined with enzalutamide. Talazoparib is a PARP inhibitor intended to enhance the effectiveness of enzalutamide, a standard treatment for prostate cancer, by targeting cancer cells with specific genetic mutations.
The study is designed as a randomized, double-blind, parallel assignment with quadruple masking, meaning neither the participants nor the care providers, investigators, or outcomes assessors know who is receiving the actual drug versus the placebo. The primary purpose of the study is treatment-focused.
The study began on May 12, 2021, and its primary completion and estimated completion dates are yet to be disclosed. The last update was submitted on August 11, 2025. These dates are crucial as they indicate the study’s progress and potential timelines for results.
This study update could influence Pfizer and Astellas Pharma’s stock performance positively if the results show significant improvements in treatment outcomes, potentially increasing investor confidence. The pharmaceutical industry is highly competitive, and advancements in prostate cancer treatment could position these companies favorably against competitors.
The study is ongoing, with further details available on the ClinicalTrials portal.