Immatics Advances IMA203 to Phase 3 Trial in Melanoma

Immatics (IMTX) has released an update.

Immatics has reported promising updated Phase 1b clinical data for its ACTengine IMA203 therapy targeting PRAME in metastatic melanoma, with a 54% objective response rate and median duration of response over 12 months. Following favorable Phase 1b outcomes, including 6 months median progression-free survival (PFS) and overall survival not yet reached, Immatics is advancing to a Phase 3 trial, SUPRAME, to further assess IMA203’s efficacy. The SUPRAME trial aims to enroll 360 patients and will use median PFS as the primary endpoint for full approval.

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