Eli Lilly And Company ((LLY)) announced an update on their ongoing clinical study.
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Study Overview: The clinical trial titled A Trial of AAVAnc80-hOTOF Gene Therapy in Individuals With Sensorineural Hearing Loss Due to Otoferlin Gene Mutations aims to evaluate the safety and tolerability of a gene therapy for individuals with sensorineural hearing loss caused by otoferlin gene mutations. This study is significant as it explores a potential treatment for a genetic form of hearing loss, which could lead to new therapeutic options for affected individuals.
Intervention/Treatment: The intervention being tested is a combination product called AAVAnc80-hOTOF, administered via the Akouos Delivery Device. This gene therapy is designed to be delivered directly into the cochlea to address hearing loss at the genetic level.
Study Design: This interventional study follows a non-randomized, sequential model with no masking. It primarily aims to assess treatment effects. Participants are divided into cohorts to receive varying doses of the gene therapy, with some eligible for bilateral administration.
Study Timeline: The study began on February 8, 2023, and is currently recruiting participants. The last update was submitted on August 29, 2025. These dates highlight the study’s progress and ongoing nature, indicating active development and data collection phases.
Market Implications: Eli Lilly’s involvement in this innovative gene therapy trial could positively influence its stock performance by showcasing its commitment to cutting-edge treatments. Success in this trial may enhance investor sentiment and position Eli Lilly favorably against competitors in the gene therapy space.
The study is ongoing, with further details available on the ClinicalTrials portal.