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Denali Therapeutics Discontinues DNL343 ALS Trial

Story Highlights
  • Denali’s Phase 2/3 trial of DNL343 showed no treatment effect on ALS biomarker.
  • The trial did not meet its primary endpoint, leading to the discontinuation of the extension.
  • Looking for the best stocks to buy? Follow the recommendations of top-performing analysts.
Denali Therapeutics Discontinues DNL343 ALS Trial

Denali Therapeutics ( (DNLI) ) just unveiled an update.

On March 5, 2025, Denali Therapeutics announced that further analyses from the Phase 2/3 HEALEY ALS Platform Trial of DNL343 did not show a treatment effect on neurofilament light, a biomarker of neuronal damage, over a 24-week period. The study, which also did not meet its primary endpoint of slowing ALS disease progression, will lead to the discontinuation of the active treatment extension. Despite these results, DNL343 was found to be safe and well tolerated, and Denali plans to explore future development opportunities for the drug.

More about Denali Therapeutics

Denali Therapeutics Inc. operates in the biotechnology industry, focusing on developing therapies for neurodegenerative diseases.

YTD Price Performance: -23.46%

Average Trading Volume: 1,014,929

Technical Sentiment Consensus Rating: Strong Buy

Current Market Cap: $2.32B

For a thorough assessment of DNLI stock, go to TipRanks’ Stock Analysis page.

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