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Cellectis Showcases Safer Epigenetic Gene-Silencing Platform Ahead of ASGCT 2026

Story Highlights
  • On April 27, 2026, Cellectis unveiled TALE-based epigenetic editing data to be presented at ASGCT.
  • New TALEM screen achieved durable 90% gene knockdown, strengthening Cellectis’ gene-editing toolbox.
  • Looking for the best stocks to buy? Follow the recommendations of top-performing analysts.
Cellectis Showcases Safer Epigenetic Gene-Silencing Platform Ahead of ASGCT 2026

Meet Samuel – Your Personal Investing Prophet

Cellectis SA ( (CLLS) ) has shared an update.

On April 27, 2026, Cellectis announced that it is presenting new data on a TALE-based epigenetic editing platform at the American Society of Gene and Cell Therapy annual meeting in Boston, scheduled for May 11–15, 2026. The approach uses TALE-based epigenetic modulators to switch genes off without cutting or permanently altering DNA, positioning it as a potentially safer alternative to traditional genome editing.

The company reported that its high-throughput screening system identified potent TALE-based epigenetic modulators that achieved more than 90% durable knockdown of target genes in liver cells and T-cells, including a gene linked to T-cell dysfunction in cancer immunotherapy. By extending its gene-editing toolbox into epigenetic editing across multiple cell types, Cellectis underscores its innovation capabilities and reinforces its position in the competitive cell and gene therapy landscape ahead of its ASGCT poster presentation on May 13, 2026.

The most recent analyst rating on (CLLS) stock is a Buy with a $9.00 price target. To see the full list of analyst forecasts on Cellectis SA stock, see the CLLS Stock Forecast page.

Spark’s Take on CLLS Stock

According to Spark, TipRanks’ AI Analyst, CLLS is a Neutral.

The score is held back primarily by weak financial performance—persistent losses, renewed 2025 cash burn, and rising leverage—partly offset by a relatively constructive technical setup with the stock trading above several key moving averages. Valuation is constrained by negative earnings and the absence of a dividend.

To see Spark’s full report on CLLS stock, click here.

More about Cellectis SA

Cellectis S.A. is a clinical-stage biotechnology company specializing in gene editing to develop cell and gene therapies, with a core focus on allogeneic, off-the-shelf CAR T immunotherapies for oncology and other indications. Headquartered in Paris with sites in New York and Raleigh, it is vertically integrated with in-house manufacturing and is listed on Nasdaq and Euronext Growth.

Average Trading Volume: 44,244

Technical Sentiment Signal: Buy

Current Market Cap: $280.4M

For an in-depth examination of CLLS stock, go to TipRanks’ Overview page.

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