AstraZeneca ((AZN)), AstraZeneca plc ((GB:AZN)), AstraZeneca ((DE:ZEGA)), AstraZeneca plc US ((AZNCF)) announced an update on their ongoing clinical study.
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Study Overview: AstraZeneca is conducting a Phase 3 clinical trial titled DESTINY-Biliary Tract Cancer-01 to evaluate the efficacy and safety of Trastuzumab Deruxtecan (T-DXd) and Rilvegostomig compared to the standard-of-care (SoC) treatment in patients with advanced HER2-expressing biliary tract cancer. This study aims to provide a new first-line treatment option for this patient group, potentially improving outcomes where current therapies are limited.
Intervention/Treatment: The study tests two experimental interventions: Trastuzumab Deruxtecan (T-DXd) combined with Rilvegostomig, and T-DXd monotherapy. These are compared against the standard treatment of Gemcitabine, Cisplatin, and Durvalumab, aiming to enhance treatment efficacy for HER2-expressing biliary tract cancer.
Study Design: This is an interventional, randomized, open-label study with a parallel assignment. The primary purpose is treatment-focused, with no masking involved, allowing all parties to know the treatment allocations. This design helps in assessing the direct impact of the new interventions.
Study Timeline: The study began on August 12, 2024, with the last update submitted on July 23, 2025. These dates are crucial as they mark the progression and current status of the study, which is still recruiting participants. The timeline indicates the study’s ongoing nature and its potential future impact on treatment protocols.
Market Implications: The update on this study could positively influence AstraZeneca’s stock performance by showcasing its commitment to innovative cancer treatments. Successful outcomes may enhance investor confidence and position AstraZeneca favorably against competitors in the oncology market, particularly in the niche of HER2-expressing cancers.
The study is currently ongoing, with further details available on the ClinicalTrials portal.