AstraZeneca ((AZN)), AstraZeneca plc ((GB:AZN)), AstraZeneca ((DE:ZEGA)), AstraZeneca plc US ((AZNCF)) announced an update on their ongoing clinical study.
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AstraZeneca has launched a new clinical study titled ‘A Multicentre, Single-Arm, Phase 3b Study to Assess Changes in Symptoms in Adult Participants With Chronic Rhinosinusitis With Nasal Polyposis Initiating Treatment With Tezepelumab (ESSENCE).’ The study aims to evaluate the effectiveness of tezepelumab in treating chronic rhinosinusitis with nasal polyposis (CRSwNP), particularly for patients eligible for surgery, with or without asthma. This research is significant as it could provide a non-surgical treatment alternative for CRSwNP patients.
The intervention being tested is Tezepelumab, a combination product administered as a single-dose subcutaneous injection. It is designed to alleviate symptoms of CRSwNP, potentially offering a new therapeutic option for patients.
The study is designed as an open-label, single-arm, phase IIIb trial. Participants will receive tezepelumab every four weeks over a 24-week treatment period, with the primary aim of assessing treatment outcomes. There is no masking involved, and the primary purpose is treatment-focused.
The study began on December 3, 2024, with an estimated completion date yet to be determined. The last update was submitted on August 21, 2025. These dates are crucial for tracking the study’s progress and anticipating results.
This update could positively impact AstraZeneca’s stock performance by enhancing investor confidence in the company’s ability to innovate in the respiratory treatment market. As competitors also explore treatments for CRSwNP, AstraZeneca’s progress in this area could provide a competitive edge.
The study is ongoing, and further details are available on the ClinicalTrials portal.