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AstraZeneca’s New Phase III Study: A Potential Game-Changer in Liver Cancer Treatment

AstraZeneca’s New Phase III Study: A Potential Game-Changer in Liver Cancer Treatment

AstraZeneca ((AZN)), AstraZeneca plc ((GB:AZN)), AstraZeneca ((DE:ZEGA)), AstraZeneca plc US ((AZNCF)) announced an update on their ongoing clinical study.

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AstraZeneca is conducting a Phase III clinical study titled A Phase III, Randomised, Open-label, Sponsor-blinded, Multicentre Study of Rilvegostomig in Combination With Bevacizumab With or Without Tremelimumab as First-line Treatment in Patients With Advanced Hepatocellular Carcinoma. The study aims to evaluate the efficacy and safety of rilvegostomig combined with bevacizumab, with or without tremelimumab, compared to atezolizumab and bevacizumab in patients with advanced hepatocellular carcinoma (HCC) who are not candidates for curative or locoregional therapy.

The study tests three interventions: rilvegostomig, bevacizumab, and tremelimumab, administered as intravenous therapies. These drugs are intended to improve treatment outcomes for patients with advanced HCC.

This interventional study is randomized and follows a parallel assignment model with a single-blind approach, where the outcomes assessor is masked. The primary purpose is treatment, focusing on the safety and efficacy of the drug combinations.

The study began on May 6, 2025, with the last update recorded on August 4, 2025. These dates are crucial as they mark the progression and current status of the study, which is still recruiting participants.

The outcome of this study could significantly impact AstraZeneca’s stock performance and investor sentiment, as successful results may enhance the company’s competitive position in the oncology market. The study’s progress is closely watched by investors, given the potential for rilvegostomig to become a key player in HCC treatment.

The study is ongoing, with further details available on the ClinicalTrials portal.

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