AstraZeneca ((AZN)), AstraZeneca plc ((GB:AZN)), AstraZeneca ((DE:ZEGA)), AstraZeneca plc US ((AZNCF)) announced an update on their ongoing clinical study.
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AstraZeneca’s CASPIAN study is a Phase III, randomized, open-label trial aimed at evaluating the efficacy of durvalumab, with or without tremelimumab, in combination with platinum-based chemotherapy for first-line treatment in patients with extensive-stage small-cell lung cancer (SCLC). The study seeks to improve overall survival (OS) compared to standard chemotherapy alone.
The study tests two experimental treatments: durvalumab combined with tremelimumab and platinum-based chemotherapy, and durvalumab with platinum-based chemotherapy. These treatments are designed to enhance the immune response against cancer cells.
The study employs a randomized, parallel intervention model without masking, focusing on treatment efficacy. Patients are allocated in a 1:1:1 ratio across three arms, with the primary goal of assessing overall survival.
The CASPIAN study began on March 27, 2017, with primary results submitted on January 21, 2021. The last update was submitted on July 15, 2025, indicating ongoing data collection and analysis.
This study’s positive results could bolster AstraZeneca’s market position, potentially boosting its stock performance. The success of durvalumab in SCLC could enhance investor confidence, especially in the competitive oncology market where innovation is crucial.
The CASPIAN study is ongoing, with further details available on the ClinicalTrials portal.