AstraZeneca ((AZN)), Bayer AG ((BAYRY)), AstraZeneca plc ((GB:AZN)), Bayer Ag (UK) ((GB:0P6S)), AstraZeneca ((DE:ZEGA)), AstraZeneca plc US ((AZNCF)) announced an update on their ongoing clinical study.
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The recent clinical study update from AstraZeneca and Bayer focuses on the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary efficacy of AZD5305 in combination with new hormonal agents for patients with metastatic prostate cancer. Officially titled ‘A Multi-arm, Open-label Phase I/IIa Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy of AZD5305 in Combination With New Hormonal Agents in Patients With Metastatic Prostate Cancer (PETRANHA),’ this study aims to explore innovative treatment options for a challenging condition.
The study tests AZD5305, an experimental drug, in combination with various new hormonal agents such as Enzalutamide, Abiraterone Acetate, Darolutamide, and Apalutamide. These combinations are designed to enhance treatment efficacy for metastatic prostate cancer patients.
This interventional study is non-randomized with a parallel assignment model and no masking, focusing primarily on treatment. It is structured in two parts: Part A for dose escalation and Part B for dose expansion, involving multiple arms to assess different combinations.
The study began on June 2, 2022, with primary completion expected in 2025. The latest update was submitted on August 13, 2025, indicating ongoing recruitment and progress.
For AstraZeneca and Bayer, this study could significantly impact their stock performance and investor sentiment, particularly if results show promising efficacy and safety. In a competitive industry, breakthroughs in prostate cancer treatment can enhance market positioning and drive stock value.
The study is ongoing, with further details available on the ClinicalTrials portal.