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Ascletis Posts Positive U.S. Phase II Data for Monthly GLP-1 Obesity Drug ASC30

Story Highlights
  • Ascletis’ ASC30 A1 depot showed significant 7.5 percent placebo-adjusted weight loss at week sixteen after three monthly doses.
  • ASC30 A1 maintained weight loss up to four months post-final dose with GLP-1 class-consistent safety, enabling potential quarterly maintenance therapy.
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Ascletis Posts Positive U.S. Phase II Data for Monthly GLP-1 Obesity Drug ASC30

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Ascletis Pharma, Inc. ( (HK:1672) ) just unveiled an update.

Ascletis Pharma reported positive topline data from a 24-week U.S. Phase II trial of its ultra-long-acting subcutaneous depot formulation of small molecule GLP-1 receptor agonist ASC30 in obese or overweight patients. The A1 formulation delivered statistically significant, clinically meaningful placebo-adjusted weight loss of 6.3% at week 12 and 7.5% at week 16 after three once-monthly 400 mg doses, without any lead-in weekly injections.

The study also showed that ASC30 A1 maintained therapeutic drug exposure and sustained weight loss for up to four months after the final dose, supporting potential once-monthly treatment and once-quarterly maintenance regimens. Both A1 and A2 formulations demonstrated a safety and tolerability profile consistent with the GLP-1 class, with only mild to moderate adverse events and no discontinuations, positioning Ascletis as an emerging competitor in the rapidly expanding obesity drug market.

The most recent analyst rating on (HK:1672) stock is a Hold with a HK$13.50 price target. To see the full list of analyst forecasts on Ascletis Pharma, Inc. stock, see the HK:1672 Stock Forecast page.

More about Ascletis Pharma, Inc.

Ascletis Pharma Inc. is a biotechnology company listed in Hong Kong that focuses on developing innovative therapeutics, with a current emphasis on metabolic diseases such as obesity. The group advances small-molecule drug candidates targeting high-growth segments of the global pharmaceutical market, aiming to capture demand for next-generation GLP-1 receptor agonists.

Average Trading Volume: 3,070,477

Technical Sentiment Signal: Buy

Current Market Cap: HK$15.63B

For a thorough assessment of 1672 stock, go to TipRanks’ Stock Analysis page.

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