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Arrowhead Pharmaceuticals Advances RNAi Therapeutics Pipeline

Arrowhead Pharmaceuticals Advances RNAi Therapeutics Pipeline

Arrowhead Pharmaceuticals, Inc. ( (ARWR) ) has released its Q3 earnings. Here is a breakdown of the information Arrowhead Pharmaceuticals, Inc. presented to its investors.

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Arrowhead Pharmaceuticals, Inc. is a biotechnology company specializing in the development of RNA interference (RNAi) therapeutics aimed at treating intractable diseases by silencing the genes responsible for them. The company leverages a broad portfolio of RNA chemistries and efficient delivery mechanisms to induce gene knockdown, positioning itself as a leader in the RNAi sector.

In its fiscal 2025 third-quarter earnings report, Arrowhead Pharmaceuticals highlighted significant progress in its clinical and business development activities. The company continues to advance its pipeline, with four candidates in pivotal Phase 3 studies and a strategic commercial buildout in anticipation of potential regulatory approvals.

Key financial metrics revealed that Arrowhead recorded a revenue of $27.8 million for the quarter, with operating expenses totaling $193.3 million, resulting in an operating loss of $165.6 million. Despite the losses, the company maintains a robust cash position with total cash resources of $900.4 million, reflecting its strong financial foundation. Strategic partnerships have also been a focal point, with Arrowhead securing a $100 million milestone payment from Sarepta Therapeutics and a $130 million upfront payment from Sanofi through its subsidiary Visirna Therapeutics.

The company has made notable strides in its clinical trials, including the completion of enrollment in several Phase 3 studies for its investigational drug plozasiran, and the initiation of a Phase 3 trial for zodasiran. Arrowhead’s strategic collaborations and clinical advancements underscore its commitment to bringing innovative treatments to market.

Looking ahead, Arrowhead Pharmaceuticals remains focused on advancing its pipeline and achieving key milestones. The company’s management expresses confidence in its ability to navigate the regulatory landscape and deliver new therapies to patients, supported by a strong financial position and strategic partnerships.

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