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Allogene Therapeutics Advances Clinical Trials and Extends Cash Runway

Allogene Therapeutics ( (ALLO) ) has released its Q1 earnings. Here is a breakdown of the information Allogene Therapeutics presented to its investors.

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Allogene Therapeutics, a clinical-stage biotechnology company based in South San Francisco, is pioneering the development of allogeneic CAR T cell products for cancer and autoimmune diseases. The company focuses on creating ‘off-the-shelf’ therapies that are readily available and scalable.

In its latest earnings report for the first quarter of 2025, Allogene Therapeutics highlighted significant progress in its clinical trials and strategic initiatives. The company is advancing its pivotal Phase 2 ALPHA3 trial for large B-cell lymphoma and preparing for the international expansion of this trial. Additionally, Allogene is set to begin the Phase 1 RESOLUTION trial for autoimmune diseases and will present new data at the upcoming ASCO Annual Meeting.

Key financial metrics for the quarter include research and development expenses of $50.2 million and a net loss of $59.7 million. The company ended the quarter with $335.5 million in cash and investments, and strategic cost realignment efforts are expected to extend the cash runway into the second half of 2027. These efforts include prioritizing high-impact programs and reducing manufacturing operations to preserve core capabilities.

Looking ahead, Allogene Therapeutics remains focused on advancing its clinical programs through key milestones. The management is confident in its strategy to deliver innovative cell therapies and is committed to navigating the evolving macroeconomic environment while optimizing operations for sustained growth.

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