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Allergy Therapeutics’ VLP Peanut Shows Strong Immune Response in Early-Stage Trial

Story Highlights
  • Allergy Therapeutics’ Phase I/IIa PROTECT trial showed VLP Peanut induced strong, dose-dependent immunomodulation in peanut-allergic patients.
  • Interim results are seen as clinical proof of concept, supporting progression to Phase IIb trials and a potential new paradigm in peanut allergy treatment.
  • Looking for the best stocks to buy? Follow the recommendations of top-performing analysts.
Allergy Therapeutics’ VLP Peanut Shows Strong Immune Response in Early-Stage Trial

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An update from Allergy Therapeutics ( (GB:AGY) ) is now available.

Allergy Therapeutics reported positive biomarker data from its Phase I/IIa PROTECT trial of VLP Peanut, showing strong and consistent immunomodulating effects in peanut-allergic subjects. Higher doses produced marked reductions in basophil sensitivity and IgE-Fab binding to Ara h2, alongside significant increases in protective Ara h2-specific IgG and reduced skin prick test wheal sizes versus placebo.

External experts from Imperial College London and King’s College London highlighted that the degree of immune modulation seen after just three injections over two to three months rivals or exceeds responses typically achieved only after prolonged oral immunotherapy. Management said these interim results provide clinical proof of concept and, together with previously reported safety and tolerability, support rapid progression to a Phase IIb trial that will refine dosing and test efficacy via food challenges, potentially reshaping the treatment landscape for peanut allergy if later-stage trials succeed.

The most recent analyst rating on (GB:AGY) stock is a Sell with a £11.00 price target. To see the full list of analyst forecasts on Allergy Therapeutics stock, see the GB:AGY Stock Forecast page.

Spark’s Take on GB:AGY Stock

According to Spark, TipRanks’ AI Analyst, GB:AGY is a Neutral.

The score is driven primarily by very weak financial performance (declining revenue, large losses, negative cash flows, and negative equity). Technicals are mixed with oversold signals but still negative momentum, and valuation is constrained by a negative P/E and no dividend support.

To see Spark’s full report on GB:AGY stock, click here.

More about Allergy Therapeutics

Allergy Therapeutics plc is a fully integrated commercial biotechnology company specialising in allergy immunotherapies, with a focus on developing treatments for conditions such as peanut and other food allergies. The Group targets patients in major markets including the U.S. and Europe, aiming to offer alternatives to current oral and monoclonal therapies with shorter, injection-based regimens.

Average Trading Volume: 318,944

Technical Sentiment Signal: Buy

Current Market Cap: £747.2M

Learn more about AGY stock on TipRanks’ Stock Analysis page.

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