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AdAlta’s CAR-T therapy delivers strong tumour responses in advanced mesothelioma trial

Story Highlights
  • AdAlta’s AdCella unit reported strong Gen 2 BZDS1901 trial results in relapsed mesothelioma.
  • High-dose BZDS1901 showed doubled response rates and rare complete remissions, supporting expansion.
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AdAlta’s CAR-T therapy delivers strong tumour responses in advanced mesothelioma trial

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AdAlta Ltd. ( (AU:1AD) ) has provided an update.

AdAlta’s subsidiary AdCella has reported further positive clinical data from investigator-led trials in China of its Generation 2 CAR-T therapy BZDS1901 in advanced mesothelioma patients who had relapsed after or not responded to chemotherapy or immunotherapy. Fourteen patients have now received the Gen 2 product, with updated manufacturing enabling a shorter, lower-cost process and lower doses that improve scalability.

Among the 10 patients treated at the highest BZDS1901 doses, five achieved tumour shrinkage of more than 30%, implying a 50% overall response rate that is more than double typical second-line options. Two patients recorded complete disappearance of tumours on CT scans, an unusually high 20% complete response rate in this setting, and over a quarter of all treated patients showed ongoing tumour shrinkage, bolstering evidence of CAR-T persistence and supporting plans for higher dosing and further clinical development.

The most recent analyst rating on (AU:1AD) stock is a Hold with a A$0.01 price target. To see the full list of analyst forecasts on AdAlta Ltd. stock, see the AU:1AD Stock Forecast page.

More about AdAlta Ltd.

AdAlta Limited is an Australian biotechnology company developing next-generation cell and protein therapeutics, primarily through its cell therapy subsidiary AdCella. The group is focused on first-in-class CAR-T treatments targeting mesothelin, a protein overexpressed in aggressive solid tumours such as mesothelioma, certain lung cancers and various gynaecological cancers.

Technical Sentiment Signal: Strong Sell

Current Market Cap: A$10.2M

See more data about 1AD stock on TipRanks’ Stock Analysis page.

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