AtlasClear Holdings, Check-Cap Ltd., and aTyr Pharma are the 3 Penny Stocks to watch on September 16, 2025, based on TipRanks’ Penny Stock Screener tool. Penny stocks are defined as stocks that trade at or below $5 per share and have a market capitalization below $300 million.
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The Penny Stock Screener helps investors scan stocks based on numerous parameters, including Sector, Price Target Upside, Smart Score, Analyst Consensus, Dollar Volume, and Price Change.
We leveraged the tool to pick the top three penny stocks with the highest Dollar Volume as of the close on September 15, 2025. Simply put, Dollar Volume is the number of shares traded on a particular day multiplied by the day’s share price.
AtlasClear Holdings (ATCH) – AtlasClear is a tech-enabled financial firm offering efficient trading, clearing, settlement, and banking solutions for innovative products, focused on small and mid-sized institutions. On September 15, ATCH had a Dollar Volume of $493.14 million, while its stock price skyrocketed by 153%.
ATCH stock has been surging since September 12, after its wholly owned subsidiary, Wilson-Davis, reported a 295% year-over-year increase in net income for the year ending June 30, 2025. Meanwhile, revenues rose 15.5% year-over-year, and AtlasClear also introduced a new broker-dealer, Dawson James Securities, as a correspondent clearing client.
Check-Cap Ltd. (CHEK) – Check-Cap is a clinical-stage medical diagnostics company based in Israel that develops a non-invasive, capsule-based screening technology called the C-Scan system. The ingestible capsule scans the inner lining of the colon for precancerous polyps and other abnormalities. Yesterday, CHEK stock had a Dollar Volume of 274.77 million, accompanied by a stock price surge of 184%.
CHEK stock surged after announcing a merger with AI company MBody AI. The new combined company, to be named MBody AI Ltd., will focus on embodied AI for autonomous workforces. MBody AI investors will own 90% of the merged firm, while Check-Cap shareholders will hold 10%. The merger is subject to shareholder approval.
aTyr Pharma (ATYR) – aTyr Pharma is a clinical-stage biotechnology company focused on developing innovative therapies for fibrosis and inflammation based on its proprietary tRNA synthetase platform. On Monday, ATYR had a Dollar Volume of $157.38 million, while its shares plunged by over 83%.
aTyr revealed results from its Phase 3 EFZO-FIT clinical trial, which focused on efzofitimod as a treatment for patients with pulmonary sarcoidosis, a major form of interstitial lung disease. Although the clinical trial did not meet its primary endpoint, aTyr Pharma believes that efzofitimod still showed potential. The company will meet with the FDA to review results and decide further steps.
To find more penny stocks like these, you can take a look at TipRanks’ Penny Stock Screener tool. It shows a list of all penny stocks, their price movement, and other vital data.