Spero Therapeutics, Signing Day Sports, and Sg Blocks are the 3 Penny Stocks to watch on May 29, 2025, based on TipRanks’ Penny Stock Screener tool. Penny stocks are defined as stocks that trade at or below $5 per share and have a market capitalization of below $300 million.
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The Penny Stock Screener helps investors scan stocks based on numerous parameters, including Sector, Price Target Upside, Smart Score, Analyst Consensus, Dollar Volume, and Price Change.
We leveraged the tool to pick the top three penny stocks with the highest Dollar Volume as of the close on May 28, 2025. Simply put, Dollar Volume is the number of shares traded on a particular day multiplied by the day’s share price.

Spero Therapeutics (SPRO) – Spero Therapeutics is a clinical-stage biopharmaceutical company focused on developing novel treatments for rare diseases and multidrug-resistant (MDR) bacterial infections. On May 28, SPRO had a Dollar Volume of $431.22 million, while its stock price skyrocketed by 244.6%.
The share price jump came after the company announced results from a Phase 3 PIVOT-PO trial of tebipenem HBr, conducted in collaboration with GlaxoSmithKline (GSK). The study evaluated the drug as an oral treatment for complicated urinary tract infections. The company announced that the clinical trial could end early, since it has already met its primary endpoint.
Signing Day Sports (SGN) – Signing Day Sports is an American technology company that enables student athletes to go to college and continue playing their sports. The platform helps athletes market themselves to coaches and recruiters across the Nation. SGN’s Dollar Volume stood at $358.86 million yesterday, while its stock price surged by 163.9%.
The stock price jumped in reaction to SGN’s announcement of a definitive merger agreement with One Blockchain LLC, a subsidiary of BlockchAIn Digital Infrastructure Inc. The combined company will engage in cryptocurrency mining, artificial intelligence, and data center hosting for high-performance computing. The transaction is expected to close in the latter half of 2025, subject to shareholder approval and customary closing conditions.
Sg Blocks (SGBX) – Safe & Green Holdings Corp. operates as a developer, designer, and fabricator of modular structures that are safe, sustainable, and eco-friendly. SGBX had a Dollar Volume of $118.04 million on Wednesday, accompanied by a stock price gain of 124.2%.
SGBX entered into an agreement with Three Pines Leasing of Ocilla, GA. to supply multiple modular units expected to be leased by a U.S. government agency. The company’s shares rose in response to this news.
To find more penny stocks like these, you can take a look at TipRanks’ Penny Stock Screener tool. It shows a list of all penny stocks, their price movement, and other vital data.
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