vTv Therapeutics screens 1st patient in CATT1 study of cadiseglin for T1D

vTv Therapeutics announced that the first patient has been screened in the Company’s CATT1 pivotal trial evaluating cadisegliatin as an adjunct treatment of type 1 diabetes T1D . CATT1 is designed to be a registrational study and is one of several trials that will form the core of the regulatory submission for cadisegliatin, a potential first-in-class, oral, liver selective, glucokinase activator for T1D that has been dosed in over 500 subjects to date, including 300 patients with T1D and type 2 diabetes T2D . “Maintaining glycemic control remains a high and burdensome unmet need for the nearly 8 million people with T1D worldwide. Cadisegliatin is a new approach to current standards of care that is designed to regulate blood glucose levels by selectively activating glucose pathways in the liver,” said Paul Sekhri, Chairman, President and Chief Executive Officer of vTv Therapeutics. “Screening the first patient marks an important milestone for our late stage cadisegliatin program and brings us closer to our mission of delivering novel treatments that help improve the lives of millions of patients living with diabetes.” Dr. Thomas Strack, Chief Medical Officer of vTv Therapeutics added, “85% of patients with T1D experience one or two hypoglycemic episodes every week, representing an important barrier that limits optimal treatment. Cadisegliatin is designed to reactivate the glucose-regulating capacity in the liver independent of insulin to safely improve episodes of hyper- and hypoglycemia in patients with diabetes.”