vTv Therapeutics announces first participant randomized in CATT1 Phase 3 trial

vTv Therapeutics (VTVT) announced the first study participant has been randomized in the Company’s CATT1 Phase 3 trial investigating cadisegliatin as an adjunctive treatment to insulin in adults with type 1 diabetes. Cadisegliatin is a potential first-in-class, oral, liver-selective glucokinase activator for T1D that has been granted Breakthrough Therapy designation by the U.S. Food and Drug Administration (FDA) and has been well-tolerated in over 500 subjects to date with up to six months of treatment. “Despite major advances made in medical devices used to help manage blood glucose levels in people living with T1D, there have been few therapeutic advances. To date, there has not been any FDA-approved oral adjunct therapy to insulin to treat T1D. “Randomizing the first participant in CATT1 represents another key milestone for vTv’s development of cadisegliatin as a potential therapy to improve glycemic control for the nearly 1.6 million Americans living with T1D,” said Dr. Thomas Strack, Chief Medical Officer of vTv Therapeutics. “We look forward to reporting topline Phase 3 data from CATT1 in the second half of 2026.”