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Vanda Pharmaceuticals’ VGT-1849B granted Orphan Drug designation

Vanda Pharmaceuticals (VNDA) announced the FDA has granted Orphan Drug Designation for VGT-1849B, a selective peptide nucleic acid-based JAK2 inhibitor for the treatment of polycythemia vera. PV is a chronic myeloproliferative disorder characterized by aberrant hematopoiesis of myeloid lineage with exuberant red cell production and increased release of pro-inflammatory cytokines. The prevalence of PV in the United States is estimated to affect 44 to 57 per 100,000 people.

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