Traws Pharma reports results from bird flu model for tivoxavir marboxil

Traws Pharma (TRAW) announced positive topline results from ferrets infected with H5N1 bird flu, an accepted animal model for human influenza, when treated with tivoxavir marboxil as a single dose. These data are consistent with results reported in December 2024 in a murine model. The new studies reported evaluated the efficacy of a single dose of tivoxavir marboxil as a treatment for bird flu isolated from a Texas dairy worker and showed suppression of disease, with reduced viral burden in lungs. “Topline data from the ferret model testing show that tivoxavir marboxil has the potential to inhibit disease after bird flu infection,” said C. David Pauza, PhD, Chief Science Officer for Traws Pharma. “The ferret challenge study builds on the robust protection from bird flu that we observed in a murine model and broadens our understanding of the disease process and the likely range of human doses that will be needed for treatment. We are conducting a similar challenge study in non-human primates, with data expected in Q1 2025.”