Skye Bioscience (SKYE) presented a poster titled “Investigating the Efficacy of Nimacimab Alone or in Combination with Tirzepatide, and as a Maintenance Therapy Post Tirzepatide Discontinuation in a Diet-Induced Obesity Mouse Model” at Keystone’s conference, Obesity Therapeutics: Unlocking Benefits and Minimizing Side Effects. Key takeaways from the DIO studies: Nimacimab showed significant additive weight loss effects when combined with suboptimal or clinically active dose levels of tirzepatide. Nimacimab weight loss was durable after treatment discontinuation. Nimacimab treatment after tirzepatide discontinuation improved the weight rebound profile. Nimacimab weight loss was not primarily driven by caloric restriction. Nimacimab enhanced weight loss induced by semaglutide.
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