ProPhase Labs announces full USPTO approval for issuance of U.S. patent

ProPhase Labs (PRPH) announced that the United States Patent and Trademark Office has issued U.S. Patent No. 12379378-B2 for the Company’s biomarker-based systems and methods to assess progression risk in Barrett’s esophagus and esophageal adenocarcinoma. The patent issuance closely follows ProPhase’s June 17, 2025 announcement validating its BE-Smart molecular diagnostic, which achieved greater than a 95% technical success rate in detecting our patented panel of biomarkers, making it suitable for both esophageal brush cytology and forceps biopsies, advancing the early detection and management of esophageal disease. This patent builds on that momentum by protecting the core biomarker methods underlying BE-Smart.