Polyrizon announces in-vitro results for PL-16 Viral Blocker

Polyrizon (PLRZ) announced in-vitro results for its product candidate, the PL-16 Viral Blocker, a proprietary nasal gel formulation, confirming a broad-spectrum viral blocking efficacy and reversible physical mechanism. Polyrizon’s formulation was evaluated for its ability to block infection by multiple respiratory viruses, including the influenza virus H1N1, using cell models. The results demonstrated a strong protective effect, as pre-treatment with the formulation effectively prevented viral-induced cytopathic effects and maintained high cell viability following viral exposure. PL-16 Viral blocker formulation exhibited consistent and robust protection without evidence of cytotoxicity, confirming both the safety and efficacy of the composition. To further understand the mechanism underlying this antiviral effect, a complementary experiment assessed whether the observed blocking is due to irreversible viral inactivation or a reversible physical interaction. In this study, virus particles that had been pre-exposed to the formulation were subsequently separated from it prior to cell infection. Once the formulation was removed, the viruses regained their full infectivity, inducing normal cytopathic effects in host cells. This outcome clearly demonstrates that the formulation does not inactivate or “kill” the virus through a pharmacological mechanism, but rather functions as a temporary, physical barrier that prevents viral particles from reaching and entering host cells. Together, these findings provide compelling evidence that Polyrizon’s proprietary nasal formulation offers broad protection against respiratory viruses through a non-pharmacological, reversible mechanism, forming a physical shield on the mucosal surface that traps and neutralizes viral particles mechanically. The absence of cytotoxicity, together with the reversibility of the blocking effect, reinforces the formulation’s safety profile and its potential for further development as a non-pharmacological nasal protection product. Future development will include clinical studies and will be subject to applicable regulatory approvals.