Panbela announces interim data analysis for ASPIRE trial pushed to Q1 of 2025

Panbela Therapeutics announced that the interim data analysis for its ongoing ASPIRE trial is now expected to be available as soon as Q1 2025. This delay in the projected date for analysis comes as a result of the trial’s current event rate, which is lower than initially anticipated, indicating that patients have lived longer than expected. The ASPIRE trial, which is evaluating the efficacy and safety of Panbela’s lead product candidate, ivospemin, in combination with gemcitabine and nab-paclitaxel in patients with metastatic pancreatic ductal adenocarcinoma, requires 33% of the total expected events to occur before the interim analysis can be conducted. As of the latest assessment, less than half of the required events for the interim analysis have occurred. “While we initially anticipated the interim analysis to take place in mid-2024, we are encouraged by the lower-than-expected event rate, which suggests that patients in the ASPIRE trial have experienced prolonged survival,” said Jennifer Simpson, PhD, MSN, CRNP, President & Chief Executive Officer of Panbela Therapeutics. “This is a positive development for patients and underscores the potential of ivospemin in addressing a significant unmet need in the treatment of mPDAC.”